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The single-cell landscape of immunological responses of CD4+ T cells in HIV versus severe acute respiratory syndrome coronavirus 2
Purpose of review CD4+ T cell loss is the hallmark of uncontrolled HIV-1 infection. Strikingly, CD4+ T cell depletion is a strong indicator for disease severity in the recently emerged coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We reviewed recent single-cell immune profiling studies in HIV-1 infection and COVID-19 to provide critical insight in virus-induced immunopathogenesis. Recent findings Cytokine dysregulation in HIV-1 leads to chronic inflammation, while severe SARS-CoV-2 infection induces cytokine release syndrome and increased m...
Source: Current Opinion in HIV and AIDS - December 15, 2020 Category: Infectious Diseases Tags: COVID/HIV: Edited by R. Brad Jones Source Type: research

The interplay between HIV and COVID-19: summary of the data and responses to date
Conclusion COVID-19 is threatening gains against the HIV epidemic, including the U.S. Ending the HIV Epidemic goals. The ongoing collision of these two global pandemics will continue to need both study and interventions to mitigate the effects of COVID-19 on HIV efforts worldwide.
Source: Current Opinion in HIV and AIDS - December 15, 2020 Category: Infectious Diseases Tags: COVID/HIV: Edited by R. Brad Jones Source Type: research

Adaptation of advanced clinical virology assays from HIV-1 to SARS-CoV-2
Purpose of review In response to the HIV–AIDS pandemic, great strides have been made in developing molecular methods that accurately quantify nucleic acid products of HIV-1 at different stages of viral replication and to assess HIV-1 sequence diversity and its effect on susceptibility to small molecule inhibitors and neutralizing antibodies. Here, we review how knowledge gained from these approaches, including viral RNA quantification and sequence analyses, have been rapidly applied to study SARS-CoV-2 and the COVID-19 pandemic. Recent findings Recent studies have shown detection of SARS-CoV-2 RNA in blood of ...
Source: Current Opinion in HIV and AIDS - December 15, 2020 Category: Infectious Diseases Tags: COVID/HIV: Edited by R. Brad Jones Source Type: research

Prevalence of COVID-19-like symptoms among people living with HIV, and using antiretroviral therapy for prevention and treatment.
CONCLUSIONS: It appears that existing infection with HIV or receiving ART might reduce the susceptibility to the infection with SARS-CoV-2 or decrease the severity of the infection acquired. Further research is needed to understand causal mechanisms. PMID: 32652912 [PubMed - as supplied by publisher]
Source: Current HIV Research - July 11, 2020 Category: Infectious Diseases Authors: SeyedAlinaghi S, Ghadimi M, Hajiabdolbaghi M, Rasoolinejad M, Abbasian L, Nezhad MH, Manshadi SD, Ghadimi F, Ahmadinejad Z Tags: Curr HIV Res Source Type: research

COVID-19 Infection Linked to Detectable Viral Levels in HIV Patients on ART COVID-19 Infection Linked to Detectable Viral Levels in HIV Patients on ART
People with HIV who have recovered from COVID-19 infection are more likely to have detectable levels of HIV-1 RNA in their plasma than individuals with HIV but no SARS-CoV-2 co-infection, according to new research.Reuters Health Information
Source: Medscape Hiv-Aids Headlines - December 3, 2020 Category: Infectious Diseases Tags: HIV/AIDS News Source Type: news

The course of COVID-19 in four patients with HIV during the pandemic.
CONCLUSION: In this study, the effect of the immunological status of the patients on the course of COVID-19 and the developing vascular complications were evaluated in 4 patients with HIV. PMID: 33261541 [PubMed - as supplied by publisher]
Source: Current HIV Research - November 30, 2020 Category: Infectious Diseases Authors: Turken M, Altan H, Atalay S, Kose S Tags: Curr HIV Res Source Type: research

COVID-19 antibody development fueled by HIV-1 broadly neutralizing antibody research
Purpose of review The coronavirus disease 2019 (COVID-19) pandemic has caught the world unprepared, with no prevention or treatment strategies in place. In addition to the efforts to develop an effective vaccine, alternative approaches are essential to control this pandemic, which will most likely require multiple readily available solutions. Among them, monoclonal anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies have been isolated by multiple laboratories in record time facilitated by techniques that were first pioneered for HIV-1 antibody discovery. Here, we summarize how lessons learned f...
Source: Current Opinion in HIV and AIDS - December 15, 2020 Category: Infectious Diseases Tags: COVID/HIV: Edited by R. Brad Jones Source Type: research

The first 6 months of HIV-SARS-CoV-2 coinfection: outcomes for 6947 individuals
Purpose of review The aim of this review is to summarize the clinical outcomes of people living with HIV (PWH) coinfected with SARS-CoV-2 during the first six months of the COVID-19 pandemic. Recent findings Several reports from single centers have described increased, decreased, or no difference in outcomes of COVID-19 in PWH. These studies have come from a range of locations, each with different underlying HIV prevalence and access to various antiretroviral therapy (ART) regimens. Differences in healthcare quality, access and policies may also affect reported outcomes in PWH across different locations, making ...
Source: Current Opinion in HIV and AIDS - December 15, 2020 Category: Infectious Diseases Tags: COVID/HIV: Edited by R. Brad Jones Source Type: research

Fewer but More Often Severe COVID Cases in People Living With HIV, Study Suggests Fewer but More Often Severe COVID Cases in People Living With HIV, Study Suggests
People living with HIV do not appear to be at higher risk of SARS-CoV-2 infection, but they may have more severe disease than people without HIV, researchers report.Reuters Health Information
Source: Medscape Hiv-Aids Headlines - May 14, 2021 Category: Infectious Diseases Tags: HIV/AIDS News Source Type: news

SARS-CoV-2 Vaccine Immunogenicity in Older People With HIV SARS-CoV-2 Vaccine Immunogenicity in Older People With HIV
A new study provides insight into SARS-CoV-2 immunogenicity after COVID-19 vaccination in people living with HIV.HIV Medicine
Source: Medscape Hiv-Aids Headlines - March 3, 2022 Category: Infectious Diseases Tags: HIV/AIDS Journal Article Source Type: news

Effectiveness and Safety of SARS-CoV-2 Vaccination in HIV Effectiveness and Safety of SARS-CoV-2 Vaccination in HIV
A systematic review and meta-analysis looks at the immune, efficacy, and safety outcomes of the SARS-CoV-2 vaccine among people with HIV compared with people without HIV.AIDS
Source: Medscape Hiv-Aids Headlines - July 20, 2023 Category: Infectious Diseases Tags: HIV/AIDS Journal Article Source Type: news

Molecular epidemiology in the HIV and SARS-CoV-2 pandemics
Purpose of review The aim of this review was to compare and contrast the application of molecular epidemiology approaches for the improved management and understanding of the HIV versus SARS-CoV-2 epidemics. Recent findings Molecular biology approaches, including PCR and whole genome sequencing (WGS), have become powerful tools for epidemiological investigation. PCR approaches form the basis for many high-sensitivity diagnostic tests and can supplement traditional contact tracing and surveillance strategies to define risk networks and transmission patterns. WGS approaches can further define the causative agents ...
Source: Current Opinion in HIV and AIDS - December 15, 2020 Category: Infectious Diseases Tags: COVID/HIV: Edited by R. Brad Jones Source Type: research

Safety and Response to the SARS-CoV-2 mRNA Vaccine in HIV Safety and Response to the SARS-CoV-2 mRNA Vaccine in HIV
Early data provides insight into the safety and development of antibodies among people with HIV who received the first dose of the SARS-CoV-2 mRNA vaccine.AIDS
Source: Medscape Hiv-Aids Headlines - August 26, 2021 Category: Infectious Diseases Tags: HIV/AIDS Journal Article Source Type: news

Outcomes Among Persons With HIV With Suspected SARS-CoV-2 Outcomes Among Persons With HIV With Suspected SARS-CoV-2
What have we learned about the clinical characteristics and outcomes of people with HIV and SARS-CoV-2 infection? A study of emergency department patients provides some insight.JAIDS: Journal of Acquired Immune Deficiency Syndromes
Source: Medscape Hiv-Aids Headlines - November 17, 2021 Category: Infectious Diseases Tags: HIV/AIDS Journal Article Source Type: news

SARS-CoV-2 Infection Among People With and Without HIV SARS-CoV-2 Infection Among People With and Without HIV
In what ways do the symptoms, severity, and outcomes of SARS-CoV-2 infection differ between people with and without HIV?JAIDS: Journal of Acquired Immune Deficiency Syndromes
Source: Medscape Hiv-Aids Headlines - December 24, 2021 Category: Infectious Diseases Tags: HIV/AIDS Journal Article Source Type: news